JPS6234726B2 - - Google Patents
Info
- Publication number
- JPS6234726B2 JPS6234726B2 JP53063418A JP6341878A JPS6234726B2 JP S6234726 B2 JPS6234726 B2 JP S6234726B2 JP 53063418 A JP53063418 A JP 53063418A JP 6341878 A JP6341878 A JP 6341878A JP S6234726 B2 JPS6234726 B2 JP S6234726B2
- Authority
- JP
- Japan
- Prior art keywords
- streptococcus
- cells
- strain
- physiological saline
- negative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000002360 preparation method Methods 0.000 claims abstract description 25
- 230000000259 anti-tumor effect Effects 0.000 claims abstract description 11
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 claims abstract description 6
- 229930182555 Penicillin Natural products 0.000 claims abstract description 5
- 238000004519 manufacturing process Methods 0.000 claims abstract description 5
- 229940049954 penicillin Drugs 0.000 claims abstract description 5
- 241000194017 Streptococcus Species 0.000 claims description 29
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 7
- 238000011282 treatment Methods 0.000 abstract description 5
- 238000010438 heat treatment Methods 0.000 abstract description 4
- 241000264435 Streptococcus dysgalactiae subsp. equisimilis Species 0.000 abstract 1
- 239000012266 salt solution Substances 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 description 23
- 230000001580 bacterial effect Effects 0.000 description 21
- 239000002504 physiological saline solution Substances 0.000 description 16
- 206010028980 Neoplasm Diseases 0.000 description 15
- 239000000725 suspension Substances 0.000 description 13
- 230000000694 effects Effects 0.000 description 11
- 241001465754 Metazoa Species 0.000 description 9
- 239000002609 medium Substances 0.000 description 9
- 239000000203 mixture Substances 0.000 description 9
- 238000002054 transplantation Methods 0.000 description 9
- 239000000243 solution Substances 0.000 description 6
- 241000894006 Bacteria Species 0.000 description 5
- 241000699670 Mus sp. Species 0.000 description 5
- 241000193996 Streptococcus pyogenes Species 0.000 description 5
- 210000004881 tumor cell Anatomy 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- 238000009472 formulation Methods 0.000 description 4
- 235000006109 methionine Nutrition 0.000 description 4
- 229930182817 methionine Natural products 0.000 description 4
- 239000000843 powder Substances 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- NHBKXEKEPDILRR-UHFFFAOYSA-N 2,3-bis(butanoylsulfanyl)propyl butanoate Chemical compound CCCC(=O)OCC(SC(=O)CCC)CSC(=O)CCC NHBKXEKEPDILRR-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 230000002949 hemolytic effect Effects 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 239000013641 positive control Substances 0.000 description 3
- -1 BBM (Yaltose Chemical compound 0.000 description 2
- 239000004470 DL Methionine Substances 0.000 description 2
- 208000003468 Ehrlich Tumor Carcinoma Diseases 0.000 description 2
- 206010018910 Haemolysis Diseases 0.000 description 2
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 description 2
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 2
- QIAFMBKCNZACKA-UHFFFAOYSA-N N-benzoylglycine Chemical compound OC(=O)CNC(=O)C1=CC=CC=C1 QIAFMBKCNZACKA-UHFFFAOYSA-N 0.000 description 2
- 238000002835 absorbance Methods 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 210000000941 bile Anatomy 0.000 description 2
- 229940041514 candida albicans extract Drugs 0.000 description 2
- 150000001720 carbohydrates Chemical class 0.000 description 2
- 238000005119 centrifugation Methods 0.000 description 2
- 238000012258 culturing Methods 0.000 description 2
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 2
- 238000004108 freeze drying Methods 0.000 description 2
- FFEARJCKVFRZRR-UHFFFAOYSA-N methionine Chemical compound CSCCC(N)C(O)=O FFEARJCKVFRZRR-UHFFFAOYSA-N 0.000 description 2
- 239000002953 phosphate buffered saline Substances 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 239000012138 yeast extract Substances 0.000 description 2
- WQZGKKKJIJFFOK-SVZMEOIVSA-N (+)-Galactose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-SVZMEOIVSA-N 0.000 description 1
- KUWPCJHYPSUOFW-YBXAARCKSA-N 2-nitrophenyl beta-D-galactoside Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1OC1=CC=CC=C1[N+]([O-])=O KUWPCJHYPSUOFW-YBXAARCKSA-N 0.000 description 1
- PLXMOAALOJOTIY-FPTXNFDTSA-N Aesculin Natural products OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)[C@H]1Oc2cc3C=CC(=O)Oc3cc2O PLXMOAALOJOTIY-FPTXNFDTSA-N 0.000 description 1
- 102100032252 Antizyme inhibitor 2 Human genes 0.000 description 1
- 239000004475 Arginine Substances 0.000 description 1
- 102100035882 Catalase Human genes 0.000 description 1
- 108010053835 Catalase Proteins 0.000 description 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
- RWSOTUBLDIXVET-UHFFFAOYSA-N Dihydrogen sulfide Chemical compound S RWSOTUBLDIXVET-UHFFFAOYSA-N 0.000 description 1
- 201000000297 Erysipelas Diseases 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 1
- 101000798222 Homo sapiens Antizyme inhibitor 2 Proteins 0.000 description 1
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 1
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 description 1
- AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 description 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 1
- 108010048581 Lysine decarboxylase Proteins 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 241000699660 Mus musculus Species 0.000 description 1
- AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 description 1
- UTJLXEIPEHZYQJ-UHFFFAOYSA-N Ornithine Natural products OC(=O)C(C)CCCN UTJLXEIPEHZYQJ-UHFFFAOYSA-N 0.000 description 1
- 102000052812 Ornithine decarboxylases Human genes 0.000 description 1
- 108700005126 Ornithine decarboxylases Proteins 0.000 description 1
- 108010087702 Penicillinase Proteins 0.000 description 1
- 241001468181 Streptococcus sp. 'group C' Species 0.000 description 1
- 241000186064 Trueperella pyogenes Species 0.000 description 1
- 108010046334 Urease Proteins 0.000 description 1
- 238000009651 Voges-Proskauer test Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
- 235000003704 aspartic acid Nutrition 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- IYNDLOXRXUOGIU-LQDWTQKMSA-M benzylpenicillin potassium Chemical compound [K+].N([C@H]1[C@H]2SC([C@@H](N2C1=O)C([O-])=O)(C)C)C(=O)CC1=CC=CC=C1 IYNDLOXRXUOGIU-LQDWTQKMSA-M 0.000 description 1
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 235000018417 cysteine Nutrition 0.000 description 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- XHCADAYNFIFUHF-TVKJYDDYSA-N esculin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC(C(=C1)O)=CC2=C1OC(=O)C=C2 XHCADAYNFIFUHF-TVKJYDDYSA-N 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 230000020764 fibrinolysis Effects 0.000 description 1
- 235000013922 glutamic acid Nutrition 0.000 description 1
- 239000004220 glutamic acid Substances 0.000 description 1
- 235000013882 gravy Nutrition 0.000 description 1
- 230000008588 hemolysis Effects 0.000 description 1
- 230000036571 hydration Effects 0.000 description 1
- 238000006703 hydration reaction Methods 0.000 description 1
- 229910000037 hydrogen sulfide Inorganic materials 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 description 1
- RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 238000007912 intraperitoneal administration Methods 0.000 description 1
- 230000000877 morphologic effect Effects 0.000 description 1
- 238000011580 nude mouse model Methods 0.000 description 1
- 229960003104 ornithine Drugs 0.000 description 1
- 229940056360 penicillin g Drugs 0.000 description 1
- 229950009506 penicillinase Drugs 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 230000000405 serological effect Effects 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 230000019086 sulfide ion homeostasis Effects 0.000 description 1
- 239000007078 todd-hewitt medium Substances 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
- C12P1/04—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using bacteria
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/46—Streptococcus ; Enterococcus; Lactococcus
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Microbiology (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Mycology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Pharmacology & Pharmacy (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Priority Applications (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP6341878A JPS54157815A (en) | 1978-05-29 | 1978-05-29 | Anti-tumor substance and its preparation |
| GB7917784A GB2024857B (en) | 1978-05-29 | 1979-05-22 | Preparation containing streptococcusequisimilis |
| US06/042,419 US4349541A (en) | 1978-05-29 | 1979-05-25 | Anti-tumor preparation against certain tumors and process for preparing the same |
| CH4961/79A CH649709A5 (de) | 1978-05-29 | 1979-05-28 | Antitumor-praeparat und verfahren zu dessen herstellung. |
| DE19792921829 DE2921829A1 (de) | 1978-05-29 | 1979-05-29 | Praeparat zur behandlung maligner neoplasien und verfahren zu seiner herstellung |
| FR7913634A FR2427099A1 (fr) | 1978-05-29 | 1979-05-29 | Preparation anti-tumorale a base de cellules d'une souche de streptococcus |
| CA000328561A CA1135184A (en) | 1978-05-29 | 1979-05-29 | Anti-tumor preparation and process for preparing the same |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP6341878A JPS54157815A (en) | 1978-05-29 | 1978-05-29 | Anti-tumor substance and its preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS54157815A JPS54157815A (en) | 1979-12-13 |
| JPS6234726B2 true JPS6234726B2 (en]) | 1987-07-28 |
Family
ID=13228713
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP6341878A Granted JPS54157815A (en) | 1978-05-29 | 1978-05-29 | Anti-tumor substance and its preparation |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US4349541A (en]) |
| JP (1) | JPS54157815A (en]) |
| CA (1) | CA1135184A (en]) |
| CH (1) | CH649709A5 (en]) |
| DE (1) | DE2921829A1 (en]) |
| FR (1) | FR2427099A1 (en]) |
| GB (1) | GB2024857B (en]) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH03116624U (en]) * | 1990-03-14 | 1991-12-03 | ||
| JPH0416837U (en]) * | 1990-05-30 | 1992-02-12 |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5933223A (ja) * | 1982-08-20 | 1984-02-23 | Koken Kk | 人の悪性腫瘍細胞増殖抑制剤 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1132676A (en) * | 1966-03-08 | 1968-11-06 | Chugai Pharmaceutical Co Ltd | Anti-tumour preparation and process for preparing the same |
| GB1153113A (en) * | 1967-01-20 | 1969-05-21 | Chugai Pharmaceutical Co Ltd | Method of Treating Hemolytic Streptococci and the Resultant Preparation containing the same |
| US3632746A (en) * | 1967-08-30 | 1972-01-04 | Chugai Pharmaceutical Co Ltd | Dried stable anti-tumor preparations and process for preparing the same |
| US4002736A (en) * | 1974-12-16 | 1977-01-11 | Pankratz Duane C | Porcine bacterin |
-
1978
- 1978-05-29 JP JP6341878A patent/JPS54157815A/ja active Granted
-
1979
- 1979-05-22 GB GB7917784A patent/GB2024857B/en not_active Expired
- 1979-05-25 US US06/042,419 patent/US4349541A/en not_active Expired - Lifetime
- 1979-05-28 CH CH4961/79A patent/CH649709A5/de not_active IP Right Cessation
- 1979-05-29 FR FR7913634A patent/FR2427099A1/fr active Granted
- 1979-05-29 CA CA000328561A patent/CA1135184A/en not_active Expired
- 1979-05-29 DE DE19792921829 patent/DE2921829A1/de active Granted
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH03116624U (en]) * | 1990-03-14 | 1991-12-03 | ||
| JPH0416837U (en]) * | 1990-05-30 | 1992-02-12 |
Also Published As
| Publication number | Publication date |
|---|---|
| GB2024857A (en) | 1980-01-16 |
| CA1135184A (en) | 1982-11-09 |
| JPS54157815A (en) | 1979-12-13 |
| DE2921829A1 (de) | 1979-12-06 |
| GB2024857B (en) | 1982-08-04 |
| US4349541A (en) | 1982-09-14 |
| CH649709A5 (de) | 1985-06-14 |
| FR2427099B1 (en]) | 1983-11-18 |
| DE2921829C2 (en]) | 1987-08-13 |
| FR2427099A1 (fr) | 1979-12-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US4347240A (en) | Antitumor agent containing Lactobacillus casei YIT 9018 | |
| JPS615022A (ja) | 腸内細菌叢改善剤 | |
| CA1266234A (en) | Method of binding microflora | |
| Anderson et al. | Synthesis and release of polyribophosphate by Haemophilus influenzae type b in vitro | |
| Lovett et al. | Identification of Bacillus subtilis NRRL B-3275 as a strain of Bacillus pumilus | |
| Smith et al. | Comparative effect of two strains of C. parvum on phagocytic activity and tumour growth | |
| US4731245A (en) | Vaccine, antigen and antibody for treating microorganisms of the MCLS-type streptococcus sanguis | |
| JPS6234726B2 (en]) | ||
| US4479935A (en) | Fractions extracted from aerobic bacteria, endowed with antitumoral, antibacterial and interferon inducing properties, and process for their preparation | |
| EP0148025B1 (en) | Antibodies and antibody-containing compositions for inhibiting periodontitis | |
| ES337684A1 (es) | Metodo para tratar las celulas de streptococcus hemolyti- cus. | |
| Takazoe et al. | Experimental formation of" corn cob" in vitro | |
| SU997599A3 (ru) | Способ получени гетеровакцины дл лечени синдрома трихомонада | |
| US3632746A (en) | Dried stable anti-tumor preparations and process for preparing the same | |
| RU2098127C1 (ru) | Ассоциированная вакцина "нековак" против некробактериоза крупного рогатого скота | |
| JPH0149246B2 (en]) | ||
| CN114748615A (zh) | 一种治疗用重组卡介苗的冻干制剂及其制备方法和用途 | |
| JPH09227392A (ja) | 抗腫瘍剤及びその製造法 | |
| JPS6011686B2 (ja) | 新規な抗腫瘍剤 | |
| JPH0699314B2 (ja) | マクロフア−ジ活性化剤 | |
| RU2101020C1 (ru) | Препарат, обладающий иммуностимулирующим действием | |
| JPS6324977B2 (en]) | ||
| KR890003942B1 (ko) | 스트렙토코쿠스 상기스의 mcls형 미생물 처리용 항체의 제조방법 | |
| KR880001949B1 (ko) | 히아론산의 제조방법 | |
| KR100279844B1 (ko) | 치주염 원인세균인 포필로모나스 진지발리스 세포를 용균시키는 용균효소 와이유205와 그를 생산하는 미생물 |